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Treatment of 15 mCRPC patients with abiraterone acetate plus 10 mg prednisolone resulted in median prednisolone plasma concentrations of 152 nM—equivalent to 608 nM cortisol—thus providing physiologic glucocorticoid replacement ( Fig. 4) [ 16 ]. At this dose, the mineralocorticoid activity of prednisolone is minimal [ 19 ]. Figure 4. Web.

However, in pts on 10 mg or more of prednisone, weaning the dose to lower levels helps reduce the risk of bone loss. Sometimes, this requires the use of helper drugs such as methotrexate, imuran or cellecpt. ... I only use prednisone with the average dosage being 20-40 mg. I work and maintain my lifestyle; with my eyes wide open to the probable.

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blurred vision decrease in the amount of urine dizziness fast, slow, pounding, or irregular heartbeat or pulse headache irritability mood changes noisy, rattling breathing numbness or tingling in the arms or legs pounding in the ears shortness of breath swelling of the fingers, hands, feet, or lower legs trouble thinking, speaking, or walking.

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